Can Renal Parameters Predict the Mortality of Hospitalized COVID-19 Patients?

Introduction: Our study aimed to analyze whether renal parameters can predict mortality from COVID-19 disease in hospitalized patients. Methods: This retrospective cohort includes all adult patients with confirmed COVID-19 disease who were consecutively admitted to the tertiary hospital during the four-month period (1.9. - 31.12.2020). We analyzed their basic laboratory values, urinalysis, comorbidities, length of hospitalization, and survival. The RIFLE and KDIGO criteria were used for AKI and CKD grading, respectively. To display renal function evolution and the severity of renal damage, we subdivided patients further into 6 groups as follows: group 1 (normal renal function), group 2 (CKD grade 2+3a), group 3 (AKI-DROP defined as whose s-Cr dropped by>33.3% during the hospitalization), group 4 (CKD 3b), group 5 (CKD 4+5) and group 6 (AKI-RISE defined as whose s-Cr was elevated by ≥ 50% within 7 days or by ≥26.5 μmol/L within 48-hours during hospitalization). Then, we used eGFR on admission independently of renal damage to check whether it can predict mortality. Only 4 groups were used: Group I – normal renal function (eGFR>1.5 ml/s), group II mild renal involvement (eGFR 0.75-1.5), group III - moderate (eGFR 0.5-0.75) and group IV – severe (GFR
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research