Response to Comment on Hamblin et al. Capillary Ketone Concentrations at the Time of Colonoscopy: A Cross-Sectional Study With Implications for SGLT2 Inhibitor –Treated Type 2 Diabetes. Diabetes Care 2021;44:e124–e126

We thank Dr. Thiruvenkatarajan et al. (1) for their interest in our article (2). In developing the reference interval for blood ketone concentrations, we used the widely cited approved recommendation from the International Federation of Clinical Chemistry (IFCC) Expert Panel for dealing with nonparametric data by using the central 95% of the data set (3). We have strong concerns that referencing an opinion piece published in theWikiJournal of Medicine should form the basis for departing from this internationally accepted methodology for establishing reference intervals.
Source: Diabetes Care - Category: Endocrinology Source Type: research