Dual-pharmacophore DNA-encoded chemical libraries.

Dual-pharmacophore DNA-encoded chemical libraries.
Curr Opin Chem Biol. 2015 Mar 13;26:99-103
Authors: Scheuermann J, Neri D
Abstract
In contrast to single-pharmacophore DNA-encoded libraries, where only one chemical moiety is linked to DNA, dual-pharmacophore DNA-encoded chemical libraries feature the display of two independent small-molecules in close proximity. This, in principle, allows to explore adjacent epitopes on a pharmaceutical target of choice and hence the discovery of simultaneously binding pairs of fragments, by virtue of the chelate effect.
PMID: 25779969 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - March 13, 2015 Category: Biochemistry Authors: Scheuermann J, Neri D Tags: Curr Opin Chem Biol Source Type: research