Outcomes of Implementing an Infectious Diseases Approval of Selected Antimicrobials as an Antimicrobial Stewardship Initiative in a Referral Hospital in Iran

This study is a quasiexperimental study that focused on the consumption of the 5 costly antimicrobial drugs, including liposomal amphotericin B, caspofungin, colistimethate sodium, linezolid, and voriconazole between preintervention and postintervention plans (2016–2018). If the antimicrobial was not approved by the infectious disease physician, possible alternative medications were used. Indexes, including total consumption rate, per capita consumption, total cost, per capita cost, mortality rate, and length of hospital stay, were measured annually. Results There were 29,268 and 27,704 hospitalized patients that were screened primarily. Among them, 600 patients were eligible for each preintervention and postintervention phases. After the intervention, defined daily dose dropped by 18.23%, 25.51%, 9.56%, and 31.56% for amphotericin B, colistimethate sodium, caspofungin, and voriconazole, respectively. The expenditure of restricted antimicrobials decreased by 34.98% in the postimplementation of antimicrobial stewardship program (P
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Original Articles Source Type: research