Megakaryocyte-stromal cell interactions: effect on megakaryocyte proliferation, proplatelet production, and survival

The bone marrow (BM) microenvironment is composed of different stromal cell types, extracellular matrix components and soluble/humoral factors, which provide physical support and modulate survival, proliferation and maturation of hematopoietic stem and committed cells, including megakaryocytes (MKs) (1). Megakaryopoiesis is closely regulated by both, transcription factors and signals derived from the interaction of hematopoietic stem cells with BM environmental cells (2, 3). Despite numerous advances in recent years regarding the mechanisms involved in megakaryopoiesis and thrombopoiesis, there are still a number of unanswered questions concerning stromal cell function during these processes.

Source: Experimental Hematology - January 12, 2022 Category: Hematology Authors: Nora P. Goette, Francisco R. Borzone, Ailen D. Discianni Lupi, Norma A. Chasseing, Mar ía F. Rubio, Mónica A. Costas, Paula G. Heller, Rosana F. Marta, Paola R. Lev Tags: Article Source Type: research