C/EBP β sustains the oncogenic program of AML cells by cooperating with MYB and co-activator p300 in a transcriptional module

The MYB gene was initially discovered as the cellular progenitor of the retrovirally-transduced oncogene v-myb of avian leukemia virus (AMV), an agent that causes myeloid leukemia in chickens. Subsequent work showed that MYB encodes a transcription factor (MYB) that is highly expressed in hematopoietic progenitor cells and supports their proliferation and differentiation (for review see [1]). MYB binds to a short consensus nucleotide motif via an N-terminal DNA-binding domain and stimulates the transcription of its target genes by a transactivation domain located in the center of the protein (Fig.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research