Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology

It is estimated that ∼5-10% of all cancers are due to pathogenic variants (PV) inherited in the germline.[1] For high-risk families, early identification of a cancer-predisposing germline PV is critical, as subsequent genetic counseling can encourage and motivate patients to adhere to risk-reducing interventions.[1] G ermline PVs in DNA repair genes are known to not only increase cancer risk but are also relevant for guiding cancer treatment. DNA repair is crucial for genome stability, with multiple specialized pathways existing in the cell to repair different types of DNA lesions (Figure 1).

Source: Cancer Treatment Reviews - January 5, 2022 Category: Cancer & Oncology Authors: Shreya M. Shah, Elena V. Demidova, Randy W. Lesh, Michael J. Hall, Mary B. Daly, Joshua E. Meyer, Martin J. Edelman, Sanjeevani Arora Source Type: research