Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins

Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAMP effector proteins protein-kinase A and EPAC are found in complexes that also contain phosphodiesterases whose presence ensures a coordinated cellular response to receptor activation events. Popeye domain containing (POPDC) proteins are the most recent class of cAMP effectors to be identified and have crucial roles in cardiac pacemaking and conduction.

Source: Journal of Molecular and Cellular Cardiology - January 5, 2022 Category: Cytology Authors: Amy J. Tibbo, Delphine Mika, Sara Dobi, Jiayue Ling, Aisling McFall, Gonzalo S. Tejeda, Connor Blair, Ruth MacLeod, Niall MacQuaide, Caglar G ök, William Fuller, Brian O. Smith, Godfrey L. Smith, Grégoire Vandecasteele, Thomas Brand, George S. Baillie Source Type: research