Insulin regulates Nedd4-2 via a PKB-dependent mechanism in HEI-OC1 auditory cells-crosstalks with sphingolipid and cAMP signaling

CONCLUSIONS: Insulin induces phosphorylation of Nedd4-2, most likely involving PI3K/PKB signaling. Sphingosine 1-phosphate might protect Nedd4-2 against ceramide-induced insulin resistance.SIGNIFICANCE: Insulin-mediated regulation of Nedd4-2 might impact on inner ear sodium homeostasis with implications for diabetes-induced inner ear damage.PMID:34962430 | DOI:10.1080/00016489.2021.2016952

Source: Acta Oto-Laryngologica - December 28, 2021 Category: ENT & OMF Authors: Ann-Ki P ålbrink Bj örn Morén Karin G Stenkula M åns Magnusson Eva Degerman Source Type: research