Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion

Phenotypic plasticity drives cancer progression, impacts on treatment response and is a major driver of therapeutic resistance. In melanoma, a regulatory axis between the MITF and BRN2 transcription factors has been reported to promote tumor heterogeneity by mediating switching between proliferative and invasive phenotypes respectively. Despite strong evidence that subpopulations of cells that exhibit a BRN2high/MITFlow expression profile switch to a predominantly invasive phenotype, the mechanisms by which this switch is propagated and promotes invasion remain poorly defined.

Source: Journal of Investigative Dermatology - December 24, 2021 Category: Dermatology Authors: Mitchell E. Fane, Yash Chhabra, Loredana Spoerri, Jacinta L. Simmons, Raquelle Ludwig, Elise Bonvin, Colin R. Goding, Richard A. Sturm, Glen M. Boyle, Nikolas K. Haass, Michael Piper, Aaron G. Smith Tags: Original Article Source Type: research