Shock-Induced Endothelial Dysfunction is Present in Patients With Occult Hypoperfusion After Trauma

Background: Shock-induced endothelial dysfunction, evidenced by elevated soluble thrombomodulin (sTM) and syndecan-1 (Syn-1), is associated with poor outcomes after trauma. The association of endothelial dysfunction and overt shock has been demonstrated; it is unknown if hypoperfusion in the setting of normal vital signs (occult hypoperfusion [OH]) is associated with endothelial dysfunction. We hypothesized that sTM and Syn-1 would be elevated in patients with OH when compared to patients with normal perfusion. Methods: A single-center study of patients requiring highest-level trauma activation (2012–2016) was performed. Trauma bay arrival plasma Syn-1 and sTM were measured by enzyme-linked immunosorbent assay. Shock was defined as systolic blood pressure (SBP)
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research