Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer

This study aimed to investigate the effects of polymorphisms in these genes on the susceptibility to lung cancer. Six candidate single nucleotide polymorphisms (SNPs) were genotyped using a MassARRAY platform in a discovery cohort, including 400 lung cancer patients and 400 healthy controls, and validated in a replication cohort, including 529 lung cancer cases and 532 controls. Comparing the allele frequency distributions, we found that the rs1801274-G, rs511278-T and rs1883832-T were risk alleles for lung cancer (P 
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Lung cancer Source Type: research