L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

ConclusionAlthough LAT1 is reported to mediate the uptake of18F-FET into tumour cells, the levels of LAT1 expression do not correlate with the levels of18F-FET uptake inIDH-mutant astrocytomas. In particular, the lack of tracer uptake in18F-FET-negative gliomas cannot be explained by a reduced LAT1 expression. A higher LAT1 expression inIDH-mutant astrocytomas seems to be associated with a short PFS. Further studies regarding mechanisms influencing the uptake of18F-FET are necessary.
Source: EJNMMI Research - Category: Radiology Source Type: research