Correction to: Periodontitis and Rheumatoid Arthritis: The Common Thread

AbstractThe two immunoinflammatory disorders, rheumatoid arthritis (RA) and Periodontitis (PD) are characterized by synovitis, joint damage, and alveolar bone degradation, are triggered by certain inflammatory mediators and leukocyte invasion, respectively. Rheumatoid arthritis is an infectious disorder which attacks changed self-epitopes and thus affects 1% of the human population, whereas 11% of the worldwide population aged is afflicted by extreme periodontal diseases in which commensal microbes upon the tooth surface is substituted by dysbiosis of the bacterial community that facilitate chronic inflammatory periodontal tissue damage. Periodontitis and RA display similarities in terms of pathogenesis amid variations in aetiology; all diseases entail systemic inflammation fuelled by, degradation of connective tissue, pro-inflammatory cytokines, and bone deterioration. Both the disorders have significant serological, epidemiological, and therapeutic connections and also have some common risk factors like aging and smoking. Laboratory and clinical data supporting this correlation is addressed in this aetiology analysis and the possible pathways involved in connecting both the diseases i.e., periodontitis to RA are described.
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research