SGLT2 inhibitors and the risk of urinary tract infections in patients with heart failure: A pooled analysis examining safety endpoints

Kardiol Pol. 2021 Dec 6. doi: 10.33963/KP.a2021.0172. Online ahead of print.NO ABSTRACTPMID:34870320 | DOI:10.33963/KP.a2021.0172
Source: Polish Heart Journal - Category: Cardiology Authors: Source Type: research

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Discussion: This meta-analysis will evaluate the efficacy and safety of SGLT-2 inhibitors in HFpEF patients, providing evidence to the clinical use of SGLT-2 inhibitors in these patients. Systematic review registration: INPLASY2021120033
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Kardiol Pol. 2021 Dec 6. doi: 10.33963/KP.a2021.0172. Online ahead of print.NO ABSTRACTPMID:34870320 | DOI:10.33963/KP.a2021.0172
Source: Kardiologia Polska - Category: Cardiology Authors: Source Type: research
ConclusionASA scores are routinely assessed in clinical practice and predict a wide range of postoperative complications among hip fracture patients. Since many complications may be preventable through adequate drug treatment, rehabilitation, and risk awareness, future studies should examine the mechanisms linking ASA scores to complication risk in order to improve preventive strategies. Particularly, the high risk of cardiovascular complications among patients with high ASA scores deserves clinical and scientific attention.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Discussion Child abuse or non-accidental trauma is a clinical diagnosis. It is the constellation of history, physical examination, radiographic evaluation, laboratory testing and investigation that determines if child abuse has occurred. Irritability caused by fractures or other trauma can be a presenting symptom of abuse. Fractures can be a presentation but they are also common problems not associated with abuse. Femoral shaft fractures are estimated to account for only 1.6% of all fractures in children, therefore they are potentially more suspicious for child abuse. A review of femur fractures can be found here. A review...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
TITUSVILLE, N.J. – October 14, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today 11* abstracts highlighting data from its pulmonary hypertension (PH) portfolio will be presented at CHEST 2021, the annual meeting of the American College of Chest Physicians, held virtually October 17-20.Data presentations from eight abstracts will provide additional evidence supporting the role of objective multiparameter risk assessment approaches in helping to optimize treatment and care for pulmonary arterial hypertension (PAH), as well as the impact of earlier and comprehensive therapy with U...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Purpose of review This review discusses current evidence and future perspectives for use of SLT2 inhibitors in kidney transplant recipients (KTRs). Recent findings Sodium-Glucose-Transporter-2 inhibitors (SGLT2is) lower plasma glucose in patients with type 2 diabetes, and protect against heart failure and progression of chronic kidney disease by a glucose-independent mechanism. Most of the current studies with SGLT2is in kidney transplant patients are however short-term retrospective case studies. These, together with one small randomized clinical trial, show that SGLT2is lower glucose also in KTRs with type 2 d...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: DIALYSIS AND TRANSPLANTATION: Edited by David J. Cohen Source Type: research
Abstract: Sodium–glucose cotransporter-2 (SGLT-2) inhibitors showed benefit in patients with heart failure. In this updated meta-analysis, we evaluate the therapeutic efficacy and safety of SGLT-2 inhibitors in patients with heart failure. Different electronic databases were searched to find relevant articles. RevMan 5.4 was used for pooling data using a random/fixed-effects model, complemented by several sensitivity and subgroup analyses. A total of 13 randomized clinical trials including 14,618 patients with heart failure were included in analysis among 6797 studies screened. The overall mortality rate was 12.4...
Source: Journal of Cardiovascular Pharmacology - Category: Cardiology Tags: Review Article Source Type: research
EMPEROR-Preserved Clinical Trial is an important study which has shown benefit in patients with heart failure and a preserved ejection fraction (HFpEF) [1]. It was a double blind randomized trial in which 5988 patients with class II-IV heart failure and ejection fraction above 40% were allocated to receive empagliflozin 10 mg daily or placebo, in addition to usual therapy. The median ejection fraction noted in the study patients was 54%, with two thirds of patients having a left ventricular ejection fraction of 50% or more. Primary outcome measure in the study was a composite of cardiovascular death or hospitalization for...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
AbstractObjectivesTo investigate the association between pre-admission waiting time and postoperative complications, length of stay (LOS), and costs during hospitalization.MethodThis was a single-center, observational study. The subjects of this study were elderly hip fracture patients who were admitted to the Department of Orthopedics, West China Hospital, Sichuan University, from December 2010 to June 14, 2017, and that underwent internal fixation or joint replacement surgery. The pre-admission waiting time was treated as a categorical variable according to median and first quartile values. Outcomes included postoperativ...
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
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