FDA Expands Pembrolizumab Approval for Advanced Melanoma FDA Expands Pembrolizumab Approval for Advanced Melanoma

The expanded approval is for the adjuvant treatment of advanced melanoma after complete resection in patients aged 12 years and older.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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Melanoma skin cancer patients will soon be able to get pembrolizumab, a 'striking' new drug treatment on the NHS that turbo-boosts their immune system.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study aimed to assess the utility of quantitative high-resolution computed tomography (HRCT) for determining the clinical course of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis-associated interstitial lung disease (MDA5+ ILD).MethodThis study retrospectively analyzed the data of 34 patients with MDA5+ ILD to determine the association between the clinical findings and extent of ILD via quantitative CT analysis at baseline and short-term follow-up. Quantified HRCT scores were evaluated as the lung severity score (LSS), percentage of opacity, and percentage of high opacity.ResultsThir...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Acta Biomater. 2022 Jan 12:S1742-7061(22)00014-9. doi: 10.1016/j.actbio.2022.01.013. Online ahead of print.ABSTRACTThe clinical success of Toll-like receptor (TLR) agonists is based on their capacity to efficiently mobilize both innate and adaptive immunity. However, rapid distribution of TLR agonists into the systemic circulation may result in systemic cytokine storms. Telratolimod (Tel) is a TLR 7/8 agonist whose structure has a hydrophobic long chain that helps to prolong its release. Despite this, the phase I study of Tel showed cytokine release syndromes in 3/35 patients. Herein, we designed an injectable phase transi...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Despite seasonal variation in malignant melanoma diagnosis being well-described, data on the annual variation in high risk melanomas is scarce.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Articles Source Type: research
CONCLUSIONS: Future studies seeking to improve SSE and sun protection among melanoma survivors might benefit from focusing on survivors who report more skin cancer risk factors, lower self-efficacy in conducting SSE, less knowledge about what abnormal skin lesions look like, more perceived barriers to sun protection behaviors, and less worry about recurrence and cancer-related distress.PMID:35028656 | DOI:10.1093/abm/kaab104
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Source Type: research
CONCLUSIONS: Currently, the responses of cells to ionizing radiation are mainly ascribed to changes of their redox conditions and increased intracellular levels of ROS, but the experiments described here suggest that a further important factor is modulation of translation through changes in biogenesis and levels of miRNAs.PMID:35030053 | DOI:10.1080/09553002.2022.2028923
Source: International Journal of Radiation Biology - Category: Radiology Authors: Source Type: research
Cureus. 2021 Dec 9;13(12):e20301. doi: 10.7759/cureus.20301. eCollection 2021 Dec.ABSTRACTCutaneous metastases occur in approximately 10% of oncology patients as a feature of a persistent solid tumor or the harbinger of recurrent neoplastic disease. However, they can be the presenting manifestation of an unsuspected visceral malignancy in one percent of previously cancer-free individuals. Metastatic skin lesions from breast carcinoma are diverse in their appearance. The clinical presentation of cutaneous metastases in three women with breast cancer is described and both the morphology of skin metastases caused by breast ca...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
CONCLUSIONS: Currently, the responses of cells to ionizing radiation are mainly ascribed to changes of their redox conditions and increased intracellular levels of ROS, but the experiments described here suggest that a further important factor is modulation of translation through changes in biogenesis and levels of miRNAs.PMID:35030053 | DOI:10.1080/09553002.2022.2028923
Source: International Journal of Radiation Biology - Category: Radiology Authors: Source Type: research
This study aimed to discuss the effect of Hedgehog signaling pathway on the proliferation and apoptosis of human malignant melanoma A375 cells and explore its possible mechanism in the proliferation and apoptosis of melanoma cells. Different concentrations of Hedgehog signaling pathway inhibitor cyclopamine (5, 10, 20 and 40 μM) were used to treat human melanoma A375 cells for 24, 48, and 72 h, and set a blank control group (0 μM). Trypan blue cell counting method was used to detect cell viability. MTT method was used to detect the inhibition rate of cell proliferation. Transwell was used to detect cell invasion, and...
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
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