Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism
In this study, we isolated a new furanocoumarin named Rutagrarin (1) along with 14 known compounds (2-15) from the aerial parts of R. graveolens and elucidated their chemical structures via various spectroscopy. We found that compound 5 promoted melanogenesis and tyrosinase activity in B16 cells. Further investigation on underlying mechanisms revealed that compound 5 activated the transcription of microtia-related transcription factors and promoted the production of melanin in B16 cells via the Akt/GSK-3β/β-catenin pathway. Therefore, we confirmed the traditional efficacy of R. graveolens and speculated that compound 5 could be used as a natural drug to treat vitiligo.PMID:34861325 | DOI:10.1016/j.fitote.2021.105094
Source: Fitoterapia - Category: Biochemistry Authors: Pazilaiti Ainiwaer Mayire Nueraihemaiti Zuopeng Li Deng Zang Lan Jiang Ying Li Haji Akber Aisa Source Type: research