Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis

In conclusion, our results demonstrated that hsa_circ_0045474 down-regulation induced macrophage autophagy in tuberculosis via miR-582-5p/ TNKS2 axis, implying a novel strategy to treat the occurrence of active pulmonary tuberculosis caused by immune escape of M. tuberculosis.PMID:34861798 | DOI:10.1177/17534259211064285
Source: Innate Immunity - Category: Allergy & Immunology Authors: Source Type: research

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This study evaluated the effect of PTB on natural anticoagulant activity and CBC indices. Ninety adults were recruited: 60 PTB patients and 30 non-TB controls. Blood specimens from each participant was tested for Proteins C and S, Antithrombin-III and CBC. Pulmonary TB was associated with significantly reduced Protein C activity (101.46 [87.61-128.3] vs 121.44 [99.50-149.8] IU/L, p= 0.038), RBC (p
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Authors: Source Type: research
Worldwide, tuberculosis of the female genital tract is a major cause of infertility in endemic countries. However, it is rare in the US. As more women who immigrate from endemic countries present for obstetrical or gynecological care, providers will need to be increasingly aware of this disease. We share an institutional experience with to increase awareness of the scope of presentations of female genital tuberculosis.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Source Type: research
Should people with HIV exhibiting tuberculosis symptoms be started on same-day antiretroviral therapy? A new review looks at the risks and benefits of this strategy.HIV Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: HIV/AIDS Journal Article Source Type: news
AbstractTuberculosis continues to be a major infectious disease burden worldwide. Increasing drug resistance to first-line agents is making treatment more difficult. Bedaquiline is an orally administered drug active againstMycobacterium tuberculosis and is indicated for patients with confirmed multi-drug-resistant tuberculosis. This review aims to identify published literature reporting on the pharmacokinetics of bedaquiline, with a focus on key factors and drug interactions that may affect its use. Findings identified multiple areas for future study. First, exposure –response relationships should be further develope...
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Tuberculosis (TB) is the leading cause of death from a single infectious agent. The estimated total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very slow, while the burden of noncommunicable diseases (NCDs) is exponentially increasing in low- and middle-income countries, where the prevention and treatment of TB disease remains a great burden, and there is enough empirical evidence (scientific evidence) to justify a greater research emphasis on the syndemic interaction between TB and NCDs. The current study was proposed to build a disease-gene network based on overlapping TB with NCDs (ove...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Tuberculosis (TB) is a major contagious disease that is one of the top 10 causes of death worldwide (World Health Organization, 2020; American Thoracic Society et al., 2017; Pai et al., 2016). TB is caused by the bacillus Mycobacterium tuberculosis, which is spread when people are infected with TB expel the bacteria into the air (American Thoracic Society et al., 2017; Pai et al., 2016). The disease typically affects the lungs (pulmonary TB) but can also affect other sites (extrapulmonary TB) (American Thoracic Society et al., 2017; Pai et al., 2016).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusions (i.e., comparable) are based on an overlap of pairwise 95 percent credible intervals.1c. PASI 90 is defined as at least 90 percent improvement from baseline in the PASI score. The PASI score grades the amount of surface area on each body region that is covered by PsO plaques and the severity of plaques for their redness, thickness, and scaliness.13 PASI 90 was not a controlled endpoint in DISCOVER-1 or -2.8,9d. TREMFYA q4w dosing is not currently FDA-approved.2e. The PsA-modified vdH-S score combines erosion and joint space narrowing scores derived from radiographs of joints in body regions impacted by PsA.14 T...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT03624F, PaperXue Jiang, Hongwei Zeng, Changyuan Duan, Qianfang Hu, Qiaomin Wu, Yang Yu, Xiaolan Yang All-inorganic CsPbBr3 perovskite quantum dots (QDs) are widely studied owing to their excellent optoelectronic properties, however they are usually hydrophobic and unstable in water that seriously limit their biomedical applications.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
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