More Evidence to Focus on Tau in Alzheimer's Disease More Evidence to Focus on Tau in Alzheimer's Disease

A comprehensive reference map provides strong evidence for metabolic brain changes in Alzheimer ’s disease.First Look
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

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Medical research and development in the context of aging has, like all other medicine, been dominated for a long time by a model in which a single disease is identified by symptoms and then treated. In the context of infectious disease and inherited conditions, this is a good way to go about the matter of investigation, treatment, and assignment of resources. A patient typically has one disease at a time, and the symptoms are distinct and clearly caused by the disease in question. Indeed, the disease paradigm arose from the modern era's long road towards ever more effective control of infectious disease. The institutions a...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
We report for the first time the development of a simple distance-based β-amyloid (Aβ) protein quantification on a paper-based device (dPAD) to screen and follow Alzheimer's disease (AD). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
TUESDAY, Jan. 25, 2022 -- Stability in body mass index (BMI) over time is associated with a better cognitive trajectory in older adults, according to a study published online Jan. 20 in Alzheimer's&Dementia. Michal Schnaider Beeri, Ph.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Condition:   Alzheimer Disease Intervention:   Behavioral: Perturbation training Sponsors:   Georgia State University;   Alzheimer's Association Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Int J Biol Macromol. 2022 Jan 21:S0141-8130(22)00131-3. doi: 10.1016/j.ijbiomac.2022.01.116. Online ahead of print.ABSTRACTThe present article reports the biogenic synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) from the extract of Acacia auriculiformis (AA) leaves using biogenic approach. Several spectral and morphological studies namely UV-vis, Fourier transform infrared (FT-IR), tunneling electron microscopy along with selected area electron diffraction (TEM/SAED), scanning electron microscopy along with energy dispersive X-ray (SEM-EDX) and X-ray diffraction (XRD) were carried out which ascerta...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
Int J Biol Macromol. 2022 Jan 21:S0141-8130(22)00130-1. doi: 10.1016/j.ijbiomac.2022.01.115. Online ahead of print.ABSTRACTProteins and their aggregation is significant field of research due to their association with various conformational maladies including well-known neurodegenerative diseases like Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) diseases. Amyloids despite being given negative role for decades are also believed to play a functional role in bacteria to humans. In this review, we discuss both facets of amyloid. We have shed light on AD, which is one of the most common age-related neurodegenerative...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
Int J Biol Macromol. 2022 Jan 21:S0141-8130(22)00132-5. doi: 10.1016/j.ijbiomac.2022.01.117. Online ahead of print.ABSTRACTDisruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is followed by aggregation via different pathways in which structurally different amyloid β oligomers can be formed. The respective toxic actions of these structurally diverse oligomers can vary significantly. Linking a particular toxic action to a structurally unique kind of amyloid β oligomers and resolv...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
CONCLUSIONS: FF improved memory deficits better than CS in an AD-induced rat model. The potential neuroprotective benefits of FF against AD may be applicable to human AD therapy with additional clinical research.PMID:35076339 | DOI:10.1080/13880209.2022.2025860
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disease that afflicts millions of people all over the world. Intracerebroventricular (ICV) injection of a sub-diabetogenic dose of streptozotocin (STZ) was established as an experimental animal model of AD. The present study was conducted to evalu ate the efficacy of curcumin nanoparticles (CNs) against the behavioral, neurochemical and histopathological alterations induced by ICV-STZ. The animals were divided into: control animals, the animal model of AD that received a single bilateral ICV microinjection of STZ, and the animals protected by a dail...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractThe greatest risk factor for development of the deadly neurodegenerative disorder known as Alzheimer ’s disease (AD) is advancing age. Currently unknown is what mediates the impact of advanced age on development of AD. Also unknown is what impact activity alterations in the entorhinal cortex (EC) has on the spread of AD pathology such as pathological tau through the brain as AD progresses. This review focuses on evidence in the literature that describes how one potential age-related change, that of glutamate-mediated increases in neuronal activity, may ultimately increase the risk of developing AD and pr...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
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