Toward Personalizing HIV Treatment and Prevention

This is the annual Rolla E. Dyer Lecture. Speaker Namandje Bumpus's laboratory uses mass spectrometry and molecular pharmacology based approaches to investigate the biotransformation of clinically used drugs by the cytochromes P450s. The cytochromes P450 are responsible for the metabolism of an estimated 75 percent of currently marketed drugs. Cytochrome P450-mediated biotransformation of drugs most often results in the production of hydrophilic metabolites that can be readily excreted from the body; however, in certain instances toxic metabolites are formed that can stimulate cell death and organ failure.For more information go tohttps://oir.nih.gov/walsAir date: 5/4/2022 3:00:00 PM
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