Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer

Mesenchyme homeobox-2 (MEOX2)-mediated regulation of glioma-associated oncogene-1 (GLI1) has been associated with poor overall survival, conferring chemoresistance in lung cancer. However, the role of MEOX2/GLI1 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)-based therapy remains unexplored in human lung cancer.

Source: European Journal of Cancer - November 26, 2021 Category: Cancer & Oncology Authors: Irlanda Peralta-Arrieta, Octavio A. Trejo-Villegas, Leonel Armas-L ópez, Hugo A. Ceja-Rangel, María del Carmen Ordóñez-Luna, Priscila Pineda-Villegas, Marco A. González-López, Blanca Ortiz-Quintero, Criselda Mendoza-Milla, Zyanya L. Zatarain-Barrón Tags: Original Research Source Type: research