World first trial of cannabis-based drug to treat aggressive brain cancer gets the go ahead

Experts at the University of Leeds will find out whether the addition of cannabis-based drug Sativex extends life for people in the UK diagnosed with glioblastoma, the most aggressive brain cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conditions:   Breast Cancer;   Brain Metastases, Adult;   Stereotactic Radiosurgery;   Whole Brain Radiotherapy Intervention:   Radiation: Stereotactic Radiosurgery Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Neurooncol Adv. 2021 Nov 27;3(Suppl 5):v75-v85. doi: 10.1093/noajnl/vdab131. eCollection 2021 Nov.ABSTRACTMelanoma is the most aggressive of the common forms of skin cancer. Metastasis to the central nervous system is one of the most common and deadly complications of this disease. Historically, melanoma patients with brain metastases had a median survival of less than 6 months. However, outcomes of melanoma patients have markedly improved over the last decade due to new therapeutic approaches, including immune and targeted therapies. Targeted therapies leverage the high rate of driver mutations in this disease, which resu...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Mol Psychiatry. 2021 Dec 2. doi: 10.1038/s41380-021-01378-6. Online ahead of print.ABSTRACTAlcohol misuse is common in many societies worldwide and is associated with extensive morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related end-organ damage. The underlying mechanisms contributing to the development of AUD are largely unknown; however, growing evidence suggests that alcohol consumption is strongly associated with alterations in DNA methylation. Identification of alcohol-associated methylomic variation might provide novel insights into pathophysiology and novel treatment targets for...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Sci Rep. 2021 Dec 2;11(1):23350. doi: 10.1038/s41598-021-02611-6.ABSTRACTThe aim of the present work is to describe the differences in rs-fMRI measures (Amplitude of low frequency fluctuations [ALFF], Regional Homogeneity [ReHo] and Functional Connectivity [FC]) between patients exposed to Androgen deprivation therapy (ADT) and a control group. Forty-nine ADT patients and fifteen PC-non-ADT patients (Controls) were included in the study. A neuropsychological evaluation and a resting-state fMRI was performed to evaluate differences in ALFF and ReHo. Region of interest (ROI) analysis was also performed. ROIs were selected am...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
io Ruggiero Intra-tumoral heterogeneity (ITH) is a complex multifaceted phenomenon that posits major challenges for the clinical management of cancer patients. Genetic, epigenetic, and microenvironmental factors are concurrent drivers of diversity among the distinct populations of cancer cells. ITH may also be installed by cancer stem cells (CSCs), that foster unidirectional hierarchy of cellular phenotypes or, alternatively, shift dynamically between distinct cellular states. Ependymoma (EPN), a molecularly heterogeneous group of tumors, shows a specific spatiotemporal distribution that suggests a link between ependym...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
day Brain tumors are the leading cause of childhood cancer deaths in developed countries. They also represent the most common solid tumor in this age group, accounting for approximately one-quarter of all pediatric cancers. Developments in neuro-imaging, neurosurgical techniques, adjuvant therapy and supportive care have improved survival rates for certain tumors, allowing a future focus on optimizing cure, whilst minimizing long-term adverse effects. Recent times have witnessed a rapid evolution in the molecular characterization of several of the common pediatric brain tumors, allowing unique clinical and biological p...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Genomic Analysis of Metastatic Brain Cancer  (study page |release notes)
Source: dbGaP, the database of Genotypes and Phenotypes - Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
ConclusionsIcotinib combined with bevacizumab or rh-endostatin has a stronger inhibitory effect on tumor growth than single-target drug in vivo, with no additional side effects.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Expert Rev Mol Med. 2021 Dec 2;23:e20. doi: 10.1017/erm.2021.20.ABSTRACTGlioblastoma (GBM) is the most common and aggressive primary brain tumour, yet little progress has been made towards providing better treatment options for patients diagnosed with this devastating condition over the last few decades. The complex nature of the disease, heterogeneity, highly invasive potential of GBM tumours and until recently, reduced investment in research funding compared with other cancer types, are contributing factors to few advancements in disease management. Survival rates remain low with less than 5% of patients surviving 5 year...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
An artificial intelligence (AI) algorithm can identify racial or ethnic healt...Read more on AuntMinnie.comRelated Reading: Baby's brain unaffected by COVID-19 during pregnancy Myocarditis linked to COVID-19 affects small number of athletes Chest CT gauges COVID-19 disease severity, mortality risk Will cancer death rates increase in wake of COVID-19? Radiologists boost AI severity quantification of COVID-19
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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