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Mimics of Prostate Cancer –Atrophylooks suspicious for adenocarcinoma at first glance.the nuclei are small and hyperchromatic.No prominent nucleoli are seen.Some glands are lined by obviously benign flattened atrophic epithelium.The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic variant of prostatic adenocarcinoma (no basal cell layer). Atypical adenomatous hyperplasiaIt may show the infiltrative architecture of cancer,lacks the cytologic features such as prominent nucleoli.The immunostain for high mol. wt. Cytokeratin will show fragmented basal cell layer in most cases.Post-Atrophic HyperplasiaPost-atrophic hyperplasia architecturally mimics adenocarcinomalacks the cytologic features.In difficult cases, the immunostain for high mol. wt. cytokeratin can be performed which would show at least a few basal cells in post-atrophic hyperplasia.Sclerosing Adenosissmall glands with infiltrative growth pattern in a cellular spindled stroma.The plump spindle cells in the stroma are nicely seen here.The lining acinar epithelial cells lack cytologic atypia – no significant nuclear or nucleolar enlargement is seenMyoepithelial differentiation in basal cells of the acini of Sclerosing adenosis is illustrated with the immunostain for muscle specific actin.Cowper's Glands They have a lobular configuration and are often associated with skeletal muscle fibersThe glands are lined by gob...

Source: Oncopathology - August 25, 2011 Category: Cancer & Oncology Tags: Mimics of Prostate cancer Source Type: blogs