Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes

Abstract Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured the amount of hyperphosphorylated microtubule associated tau (HP-τ), amyloid-β protein (Aβ) and α-synuclein (α-syn) in cases that were neuropathologically diagnosed as mixed Alzheimer’s disease (AD) and neocortical Lewy body disease (LBD) but clinically presented either as dementia due to AD or LBD, the latter including dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). Our study group consisted of 28 cases (mean age, 76.11 SE: ±1.29 years; m:f, 17:11) of which 19 were neuropathologically diagnosed as mixed AD/DLB. Clinically, 8 mixed AD/DLB cases were diagnosed as AD (cAD), 8 as DLB (cDLB) and 3 as PDD (cPDD). In addition, we investigated cases that were both clinically and neuropathologically diagnosed as either AD (pure AD; n = 5) or DLB/neocortical LBD (pure DLB; n = 4). Sections from neocortical, limbic and subcortical areas were stained with antibodies against HP-τ, Aβ and α-syn. The area covered by immunopositivity was measured using image analysis. cAD cases had higher HP-τ loads than both cDLB and cPDD and the distribution of HP...
Source: Acta Neuropathologica - Category: Neurology Source Type: research

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Source: NeuroImage - Category: Neuroscience Source Type: research
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Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
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Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
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Source: Neuroscience Research - Category: Neuroscience Source Type: research
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Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Study protocol Source Type: research
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