Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor

ConclusionsSystemic exposure of BI 425809 was altered in the presence of strong CYP3A4 modulators, corroborating in vitro results that CYP3A4 mediates a major metabolic pathway for BI 425809.Trial Registration NumberNCT02342717 (registered on 15 January 2015) and NCT03082183 (registered on 10 March 2017)
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research

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Conditions:   Schizophrenia;   Cognitive Impairment Intervention:   Device: transcranial direct current stimulation Sponsors:   The National Brain Mapping Laboratory (NBML);   University of British Columbia;   Ruhr University of Bochum;   Leibniz Research Centre for Working Environment and Human Factors;   University of Tehran Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: The findings of the study indicated that FI is an acceptable and feasible approach to be delivered during hospitalisation. The intervention will be accompanied with an intervention manual, which will be tested in a future feasibility study.PMID:35057662 | DOI:10.1177/00207640211060694
Source: The International Journal of Social Psychiatry - Category: Psychiatry Authors: Source Type: research
World J Biol Psychiatry. 2022 Jan 21:1-28. doi: 10.1080/15622975.2022.2031286. Online ahead of print.ABSTRACTBACKGROUND: In people with schizophrenia, major areas of everyday life are impaired, including independent living, productive activities, social relationships and overall quality of life. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes.AIM: The goal of the present study was to identify factors associated with motivation deficits in real-life schizophrenia, and to assess its contribution to impaired functioning and quality of life.ME...
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
This study aimed to investigate gray matter volume (GMV) abnormalities and TOM deficits in schizophrenic adolescents, and examine the relationship between them. Twenty adolescent schizophrenic patients and 25 age, sex-matched healthy controls underwent T1-weighted magnetic resonance imaging (MRI) scans, and were examined for TOM based on the Reading the Mind in the Eyes test (RMET). Univariate voxel-based morphometry (VBM) and multivariate source-based morphometry (SBM) were employed to examine alterations of two GMV phenotypes in schizophrenic adolescents: voxel-wise GMV and covarying structural brain patterns (SBPs). Com...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Conclusion: Psychiatric patients in general have poorer disease control after the COVID-19 outbreak. Patients in the community appeared to be more affected than patients residing in hostels. More efforts should be directed to screening patients with pre-existing mental health disorders to enable timely interventions.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study examined how people living with schizophrenia recognize their lived experiences in free-floating group discussions. Interpretative phenomenological and group analyses were employed to collect qualitative data from 14 patients. The identified superordinate theme was “re-figuration of suffering” including: “being treated as an object,” “encountering the self through others,” and “returning to the self.” Participants shared their traumatizing stories of being alienated, discovered the realities of their lives and responsibilities through inward an d outward observatio...
Source: Archives of Psychiatric Nursing - Category: Nursing Authors: Source Type: research
Veterans with serious mental illness (SMI) are just as likely as veterans without SMI to be vaccinated against COVID-19, according to astudy published this week inPsychiatric Services in Advance.“Because individuals with [SMI] are at higher risk for COVID-19 infection and death, COVID-19 vaccine uptake in this population is a key concern,” wrote Taona P. Haderlein, Ph.D., M.A., of the Veterans Emergency Management Evaluation Center in North Hills, Calif., and colleagues. “Researchers have noted that fear of contracting COVID-19 via COVID-19 vaccination, as well as the ‘infodemic’ of misinforma...
Source: Psychiatr News - Category: Psychiatry Tags: COVID vaccine COVID-19 serious mental illness SMI smoking vaccines veterans Source Type: research
ConclusionsFindings in relation to therapy engagement, clinical benefits, participant experience and group process offer encouragement that online delivery of mindfulness for psychosis groups may be a useful addition to mental health services for people with distressing voices.
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Br J Psychiatry. 2021 Dec 2:1-8. doi: 10.1192/bjp.2021.169. Online ahead of print.ABSTRACTBACKGROUND: Neuroimaging- and machine-learning-based brain-age prediction of schizophrenia is well established. However, the diagnostic significance and the effect of early medication on first-episode schizophrenia remains unclear.AIMS: To explore whether predicted brain age can be used as a biomarker for schizophrenia diagnosis, and the relationship between clinical characteristics and brain-predicted age difference (PAD), and the effects of early medication on predicted brain age.METHOD: The predicted model was built on 523 diffusio...
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Authors: Source Type: research
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