Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics

ConclusionsThese data, in total, demonstrate that trastuzumab, and by extension T-DM1, do not bind rat or mouse neu, underscoring the importance of species selection for safety studies investigating trastuzumab or trastuzumab-based therapeutics.

http://link.springer.com/10.1007/s10549-021-06427-w

Source: Breast Cancer Research and Treatment - October 27, 2021 Category: Cancer & Oncology Source Type: research