Nuclear Receptors and Transcription Factors in Obesity-Related Kidney Disease

Both obesity and chronic kidney disease are increasingly common causes of morbidity and mortality worldwide. Although obesity often co-exists with diabetes and hypertension, it has become clear over the past several decades that obesity is an independent cause of chronic kidney disease, termed obesity-related glomerulopathy. This review defines the attributes of obesity-related glomerulopathy and describes potential pharmacologic interventions. Interventions discussed include peroxisome proliferator-activated receptors, the farnesoid X receptor, the Takeda G-protein –coupled receptor 5, and the vitamin D receptor.

Source: Seminars in Nephrology - July 1, 2021 Category: Urology & Nephrology Authors: Bryce A. Jones, Xiaoxin X. Wang, Komuraiah Myakala, Moshe Levi Source Type: research