SARS-Cov-2 and Lung Injury: Dysregulation of Immune Response, But Not Hyperimmune Response as in "Cytokine Storm Syndrome"

Clin Respir J. 2021 Oct 21. doi: 10.1111/crj.13455. Online ahead of print.ABSTRACTSARS-CoV-2 infection can present either an asymptomatic or symptomatic; the spectrum of symptomatic infection ranges from mild to critical. A majority of patients have experienced mild symptoms with a good prognosis. But, approximately 14% of them have severe infection presenting with hypoxemia and extensive lung involvement. The current mini-review describes the dysregulation of immune response for SARS-CoV-2 viral pneumonia and virus-induced lung injury. Also, many confounding factors can increase lung injury, in addition to virus-induced lung injury. Especially in critically ill patients, confounding factors can cause the inflammatory cascade, ARDS, and mortality.PMID:34674363 | DOI:10.1111/crj.13455

Source: Respiratory Care - October 21, 2021 Category: Respiratory Medicine Authors: Serpil Öcal Source Type: research