One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Chem Commun (Camb). 2021 Oct 21. doi: 10.1039/d1cc04703e. Online ahead of print.ABSTRACTA straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.PMID:34671786 | DOI:10.1039/d1cc04703e

Source: Chemical Communications - October 21, 2021 Category: Chemistry Authors: Vahid Ahmadi Chuanxiong Nie Ehsan Mohammadifar Katharina Achazi Stefanie Wedepohl Yannic Kerkhoff Stephan Block Klaus Osterrieder Rainer Haag Source Type: research