Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant

AbstractDiterpenoid alkaloids, the main components of plants of the generaAconitum,Delphinium, andGarrya, are a group of natural products with notable chemical properties and biological activities. Several C19-diterpenoid alkaloid components fromDelphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, cervical, and vincristine-resistant cervical cancer cell lines. In the current phytochemical investigation on the seeds ofD. elatum cv. Pacific Giant, eleven new C19-diterpenoid alkaloids, elapaciline (1), meladine (2), melapacitine (3), iminoeladine (4), 19-oxopaciline (5), 19-oxopacinine (6),N-deethyldelpheline (7),N-deethylpacinine (8),N-deethyl-19-oxoeladine (9),N-deethyl-N-formyleladine (10), andN-deethyl-N-formyldelpheline (11), together with 15 known C19-diterpenoid alkaloids were isolated. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Three known diterpenoid alkaloids, 6-dehydrodelcorine (12), delelatine (23), and 6-dehydroeldelidine (24), were isolated for the first time from this plant. Six of the new C19-diterpenoid alkaloids (2,4–7, and11) and three of the known diterpenoid alkaloids (18,23, and24) were evaluated for cytotoxic activity against five human tumor cell lines.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research