GSE186089 Replication of Dengue virus in differentiating K562-megakaryocytes is promoted by virus induced suppression in the accumulation of reactive oxygen species

Contributors : Kaur Jaskaran ; Rawat Yogita ; Sood Vikas ; Periwal Neha ; Rathore Deepak ; Kumar Shrikant ; Kumar Niraj ; Bhattacharyya SankarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur study reports that over-expression of NRf2 target genes causes reduction in the ROS accumulation in differentiating cells which ultimately enhances Dengue virus replication and we also report the suppression of cell adhesion molecules and platelet specific surface markers in Dengue virus infected K562-megakaryocyte cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

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J Vector Borne Dis. 2021 Jan-Mar;58(1):97. doi: 10.4103/0972-9062.330642.NO ABSTRACTPMID:34818871 | DOI:10.4103/0972-9062.330642
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
Dengue virus (DENV) is a prevalent human pathogen, infecting approximately 400 million individuals per year and causing symptomatic disease in approximately 100 million. A distinct feature of dengue is the increased risk for severe disease in some individuals with preexisting DENV-specific immunity. One proposed mechanism for this phenomenon is antibody-dependent enhancement (ADE), in which poorly-neutralizing IgG antibodies from a prior infection opsonize DENV to increase infection of Fc gamma receptor-bearing cells. While IgM and IgG are the most commonly studied DENV-reactive antibody isotypes, our group and others have...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Nisha K. Duggal West Nile virus (WNV) and Usutu virus (USUV) are mosquito-borne flaviviruses that can cause neuroinvasive disease in humans. WNV and USUV circulate in both Africa and Europe and are closely related. Due to antigenic similarity, WNV-specific antibodies and USUV-specific antibodies have the potential to bind heterologous viruses; however, it is unclear whether this interaction may offer protection against infection. To investigate how prior WNV exposure would influence USUV infection, we used an attenuated WNV vaccine that contains the surface proteins of WNV in the backbone of a dengue virus 2 vaccine s...
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