Cancers, Vol. 13, Pages 5249: Landscape of Immune-Related Markers and Potential Therapeutic Targets in Soft Tissue Sarcoma
Cancers, Vol. 13, Pages 5249: Landscape of Immune-Related Markers and Potential Therapeutic Targets in Soft Tissue Sarcoma
Cancers doi: 10.3390/cancers13205249
Authors:
Jason Roszik
Lisa Maria Mustachio
John A. Livingston
Roman Groisberg
Roberto Carmagnani Pestana
Vivek Subbiah
Anthony P. Conley
Soft tissue sarcomas, depending on the subtype and grade, frequently recur and become metastatic after localized treatment. There is now great interest in applying immunotherapy to sarcomas to immuno-profile the different subtypes and immune monitor for prognosis. Our group previously showed that key immunotherapy target genes are present in sarcomas. Here, we extend our findings by demonstrating that sarcomas with a relatively high mutational load are likely to be more sensitive to immunotherapy compared to sarcomas with a lower mutation load. We also show that sarcomas with a higher mutation load are associated with the expression of key immune-related genes. We found that CD8+ T cells are present in sarcoma subtypes and that PD-L2 is highly expressed. These findings further define potential mechanisms behind the immunotherapy response of specific sarcoma subtypes and can be used to develop more optimal treatments in the future.
Source: Cancers - Category: Cancer & Oncology Authors: Jason Roszik Lisa Maria Mustachio John A. Livingston Roman Groisberg Roberto Carmagnani Pestana Vivek Subbiah Anthony P. Conley Tags: Article Source Type: research