Analysis of serum and endometrial progesterone in determining endometrial receptivity

This study did not analyse pregnancy outcomes. Further, the findings can only be extrapolated to HRT cycles with micronised vaginal progesterone for luteal phase support.WIDER IMPLICATIONS OF THE FINDINGSOur findings suggest that the combined benefits of different routes of progesterone administration for luteal phase support could be leveraged to ensure an adequate concentration of progesterone both in the uterus and in the bloodstream. Further studies will confirm whether this method can optimise both endometrial receptivity and live birth rate. Additionally, targeted treatment to increase P4 endometrial levels may normalise the timing of the window of implantation without needing to modify the progesterone administration day.STUDY FUNDING/COMPETING INTEREST(S)This research was supported by the IVI-RMA Valencia (1706-VLC-051-EL) and Conseller ía d’Educació, Investigació, Cultura, i esport Generalitat Valenciana (Valencian Government, Spain, GV/2018//151). Almudena Devesa-Peiro (FPU/15/01398) and Cristina Rodriguez-Varela (FPU18/01657) were supported by the FPU program fellowship from the Ministry of Science, Innovation and Universit ies (Spanish Government). P.D.-G. is co-inventor on the ERA patent, with non-economic benefits. The other authors have no competing interests.TRIAL REGISTRATION NUMBERNCT03456375.
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research