The membrane-linked adaptor FRS2{beta} fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis [Medical Sciences]

Although it is held that proinflammatory changes precede the onset of breast cancer, the underlying mechanisms remain obscure. Here, we demonstrate that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggers the proinflammatory changes that induce stroma in premalignant mammary tissues and is responsible for the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Medical Sciences Biological Sciences Source Type: research