The membrane-linked adaptor FRS2{beta} fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis [Medical Sciences]
Although it is held that proinflammatory changes precede the onset of breast cancer, the underlying mechanisms remain obscure. Here, we demonstrate that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggers the proinflammatory changes that induce stroma in premalignant mammary tissues and is responsible for the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Minoru Terashima, Yuming Wang, Mengjiao Li, Reiko Sakamoto, Mizuki Yamamoto, Naoki Itano, Yusuke Inoue, Masataka Ito, Nobuaki Yoshida, Jun-ichiro Inou Tags: Medical Sciences Biological Sciences Source Type: research
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