Shigella shuts down the pyrop-technic show

Cell Host Microbe. 2021 Oct 13;29(10):1473-1476. doi: 10.1016/j.chom.2021.09.012.ABSTRACTShigella is a highly infectious human pathogen, yet mice are naturally resistant to infection. In this issue of Cell Host & Microbe, Luchetti et al. (2021) discuss this species specificity, demonstrating that Shigella directly targets the pore-forming protein Gasdermin D for degradation, thus preventing pyroptosis to enable infection of human cells.PMID:34648738 | DOI:10.1016/j.chom.2021.09.012

Source: Cell Host and Microbe - October 14, 2021 Category: Microbiology Authors: Cristina Giogha Jaclyn S Pearson Source Type: research