Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients

AbstractWe investigated plasma YKL-40 levels and chitotriosidase (CHIT1) activity in patients with cystic fibrosis (CF) lung disease and evaluated clinically relevant factors that may affect their levels. Plasma samples were obtained from pediatric (n = 19) and adult patients (n = 15) during exacerbation, discharge, and stable period of the disease. YKL-40 levels and chitotriosidase activity were measured by enzyme-linked immunosorbent assay and fluorometric assay, respectively. Data were compared with healthy children and adults of similar age. YKL-40 levels of pediat ric and adult CF patients at all periods were significantly higher than controls (p <  0.001 andp <  0.05). CHIT1 activities of adult patients at all periods were significantly higher compared to controls (p <  0.05). On the other hand, CHIT1 activities of pediatric CF patients were similar with controls. YKL-40 levels of exacerbation period of adult CF patients were negatively correlated with forced vital capacity (FVC) (r =  − 0.800,p = 0.014) and forced expiratory volume in 1 s (FEV1) (r =  − 0.735,p = 0.008). YKL-40 levels in the exacerbation period of pediatric CF patients were negatively correlated with FVC (r =  − 0.697,p = 0.0082) and FEV1 (r =  − 0.720,p = 0.006). CHIT1 activity may be a valuable marker of chronic inflammation in adult CF patients who suffer from CF for a longer period compared to pediatric patients. ...
Source: Inflammation - Category: Allergy & Immunology Source Type: research