Cavitary retinoblastoma: A review of literature

Cavitary retinoblastoma is a rare tumor variant manifesting in form of ophthalmoscopically visible translucent cavities within the tumor. The pathogenesis of the cavitary variant is unknown. Histopathologically, the cavitary spaces represent photoreceptor differentiation in the areas adjacent to the cavitations, which might explain variable response to chemotherapy with lower risk of reactivation and good prognosis. There is, however, very little understanding about its origin, frequency, pathogenesis, and clinical significance.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Source Type: research