Integrated analysis identifies a novel lncRNA prognostic signature associated with aerobic glycolysis and hub pathways in breast cancer

In conclusion, we identified five glycolysis-related lncRNAs to construct a lncRNA signature on the basis of the glycolysis score, which could predict survival probability and glycolysis status. Moreover, hallmark gene sets associated with cell growth were significantly activated in the high-risk breast cancer patient subgroup. Overall, the lncRNA signature could function as a robust prognostic indicator and help develop novel therapeutic strategies for breast cancer patients. AbstractLong noncoding RNAs (lncRNAs) play a crucial role in cancer aerobic glycolysis. However, glycolysis-related lncRNAs are still underexplored in breast cancer. In this study, we identified the five most glycolysis-related lncRNAs in breast cancer to construct a prognostic signature, which could distinguish between patients with unfavorable and favorable prognoses. To investigate the role of signature lncRNAs in breast cancer, we profiled their expression levels in breast cancer progression cell line model. Real-time PCR revealed that the five lncRNAs could contribute to breast cancer initiation or progression. Furthermore, we observed that the levels of four lncRNAs expression had a significant trend of gradient upregulation with the addition of glycolysis inhibitor in breast cancer cells. Afterward, random forest and logistic regression were conducted to assess the model's performance in stratifying glycolysis status. Finally, a nomogram including the lncRNA signature and clinical features was de...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research