A Meta-Analysis Assessing Change in Pupillary Diameter, Accommodative Amplitude, and Efficacy of Atropine for Myopia Control

Purpose: To determine the effect of atropine on pupillary diameter, accommodative amplitude as well as myopia progression. Methods: Medical databases and Cochrane Library were systematically searched for studies from 1980 until June 2020. The primary and secondary outcomes were: a) change in pupillary diameter (PD) and accommodative amplitude (AA) and b) annualized mean change in spherical equivalent and axial length with various concentrations of atropine compared to control. Results: Thirteen trials (6 RCTs, 7 observational studies) that studied 9 atropine concentrations (0.01–1.0%) were included. The relation between atropine and change in PD and AA was nonlinear; at
Source: Asia-Pacific Journal of Ophthalmology - Category: Opthalmology Tags: Review Article Source Type: research