TRPC3 Antagonizes Pruritus in A Mouse Contact Dermatitis Model

In this study, we investigated the function of TRPC3, a canonical TRP channel highly expressed in type 1 non-peptidergic (NP1) nociceptive primary afferents and other cell types, in a mouse CD model. Though TrpC3 null mice had little deficits in acute somatosensation, they showed significantly increased scratching with CD. In addition, TrpC3 null mice displayed no differences in mechanic and thermal hypersensitivity in an inflammatory pain model, suggesting that this channel preferentially functions to antagonize CD-induced itch.

https://www.jidonline.org/article/S0022-202X(21)02222-3/fulltext?rss=yes

Source: Journal of Investigative Dermatology - September 24, 2021 Category: Dermatology Authors: Katherine Beattie, Haowu Jiang, Mayank Gautam, Mary K. MacVittie, Barbara Miller, Minghong Ma, Qin Liu, Wenqin Luo Tags: Original Article Source Type: research