Combined use of Rheology and portable Low-Field NMR in cystic fibrosis patients

As most cystic fibrosis (CF) patients progress to respiratory failure, lung functionality assessment is pivotal. We previously developed a test that indirectly monitors airways (inflammation/functional test) by measuring the spin-spin relaxation time (T2m) of the water hydrogens present in CF sputum. Here the T2m significance in the monitoring of CF lung disease was further investigated by studying the correlation of T2m with: 1) sputum viscoelasticity, 2) mucociliary clearability index (MCI)/cough clearability index (CCI) and 3) sputum average mesh-size.

Source: Respiratory Medicine - September 24, 2021 Category: Respiratory Medicine Authors: Michela Abrami, Massimo Maschio, Massimo Conese, Marco Confalonieri, Fabio Gerin, Barbara Dapas, Rossella Farra, Alessandra Adrover, Lucio Torelli, Barbara Ruaro, Gabriele Grassi, Mario Grassi Source Type: research