MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration

Biomed Pharmacother. 2021 Sep 15;143:112170. doi: 10.1016/j.biopha.2021.112170. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain. It seriously affects the quality of life of patients and consequently brings a heavy economic burden to their families and the society. Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors. It is closely related to changes in the tissue structure and function, including the progressive destruction of extracellular matrix, cell aging, cell death of the intervertebral disc (IVD), inflammation, and impairment of tissue biomechanical function. Currently, the treatment of IDD is aimed at alleviating symptoms rather than at targeting pathological changes in the IVD. Furthermore, the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway is closely related to various pathological processes in IDD, and the activation of the MAPK/ERK pathway promotes the degradation of the IVD extracellular matrix, cell aging, apoptosis, and inflammatory responses. It also induces autophagy and oxidative stress that accelerate the IVD process. In our current review, we summarize the latest developments in the negative regulation of IDD after activation of the MAPK/ERK signaling pathway and emphasize on its influe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research

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Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Condition:   Low Back Pain Intervention:   Behavioral: physical rehabilitation/physiotherapy and psychosocial group sessions Sponsor:   Hospital Universitari de Bellvitge Recruiting
Source: - Category: Research Source Type: clinical trials
An amendment to this paper has been published and can be accessed via the original article.
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Correction Source Type: research
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Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Condition:   Chronic Pain Interventions:   Drug: LY3526318;   Drug: Placebo Sponsor:   Eli Lilly and Company Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Condition:   Low Back Pain Intervention:   Other: Exercise Sponsor:   Hacettepe University Active, not recruiting
Source: - Category: Research Source Type: clinical trials
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