MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration
Biomed Pharmacother. 2021 Sep 15;143:112170. doi: 10.1016/j.biopha.2021.112170. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain. It seriously affects the quality of life of patients and consequently brings a heavy economic burden to their families and the society. Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors. It is closely related to changes in the tissue structure and function, including the progressive destruction of extracellular matrix, cell aging, cell death of the intervertebral disc (IVD), inflammation, and impairment of tissue biomechanical function. Currently, the treatment of IDD is aimed at alleviating symptoms rather than at targeting pathological changes in the IVD. Furthermore, the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway is closely related to various pathological processes in IDD, and the activation of the MAPK/ERK pathway promotes the degradation of the IVD extracellular matrix, cell aging, apoptosis, and inflammatory responses. It also induces autophagy and oxidative stress that accelerate the IVD process. In our current review, we summarize the latest developments in the negative regulation of IDD after activation of the MAPK/ERK signaling pathway and emphasize on its influe...
Pain-related injustice appraisals are a key determinant of outcomes in chronic low back pain (CLBP) [78,79] and have been defined according to appraisals of severity and irreparability of loss, externalized blame, and unfairness . The principal measure of pain-related injustice appraisal is the Injustice Experience Questionnaire (IEQ) , first developed in Canada . Quantitative findings link elevated injustice appraisal with greater ongoing pain intensity, perceived disability, and worse treatment and psychosocial outcomes across a variety of musculoskeletal conditions [22,23,68-71,74,77,83].
Condition: Low Back Pain Intervention: Behavioral: physical rehabilitation/physiotherapy and psychosocial group sessions Sponsor: Hospital Universitari de Bellvitge Recruiting
An amendment to this paper has been published and can be accessed via the original article.
This study investigated the limitations and restrictions in the most relevant brief ICF core set categories for chronic low back pain (cLBP) as automatically predicted from routinely measured outcomes using a novel, validated mapping algorithm. Materials and Methods: Of 2718 cLBP patients recruited, data from 1541 (64% females) were available from before and at the end of 6 months comprehensive outpatient rehabilitation. Assessments included the Roland Morris Disability Questionnaire (RMDQ) and Pain Disability Index (PDI) questionnaires, the percentage of patients with predicted limitations and restrictions in impor...
Condition: Chronic Pain Interventions: Drug: LY3526318; Drug: Placebo Sponsor: Eli Lilly and Company Not yet recruiting
A 37-year-old man with unremarkable medical history was referred to our nephrology department for unilateral left nephrocalcinosis, incidentally discovered on imaging for chronic low back pain (Figure 1, arrow). On clinical examination, we were struck by a lateralized overgrowth of the left hemibody (Figure 2). An abdominal computed tomography scan with 3-dimensional reconstruction made the diagnosis of medullary sponge kidney (with precaliceal canalicular ectasia predominantly seen in the lef t kidney) and did not show any other abnormality (Supplementary Figure S1).
Condition: Low Back Pain Intervention: Other: Exercise Sponsor: Hacettepe University Active, not recruiting