Epigenetic regulation of inflammation [Developmental Biology]

The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper response to infection requires precise regulation of powerful immune homing signals such as tumor necrosis factor (TNF). Dysregulation of TNF leads to inflammatory bowel diseases (IBD), but...

Source: Proceedings of the National Academy of Sciences - March 3, 2015 Category: Science Authors: Marjoram, L., Alvers, A., Deerhake, M. E., Bagwell, J., Mankiewicz, J., Cocchiaro, J. L., Beerman, R. W., Willer, J., Sumigray, K. D., Katsanis, N., Tobin, D. M., Rawls, J. F., Goll, M. G., Bagnat, M. Tags: Biological Sciences Source Type: research