GSE184362 Single-cell sequencing of tumor ecosystems in papillary thyroid carcinoma
Contributors : Weilin Pu ; Xiao Shi ; Pengcheng Yu ; Meiying Zhang ; Xiaoming Zhang ; Yulong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profiled transcriptomes of 158,577 cells from 11 patients ’ paratumors, localized/advanced tumors, initially-treated/recurrent lymph nodes and radioactive iodine (RAI)-refractory distant metastases, covering comprehensive clinical courses of PTC.Our study illuminates a comprehensive landscape of PTC ecosystem that suggests potential prognostic and therap eutic implications. Our work not only adds dimensions to the biological underpinnings of PTC heterogeneity, but also provides a benchmark dataset for this malignancy.
Appropriate timing of definitive thyroidectomy after diagnosis of papillary thyroid carcinoma (PTC) is not well-defined. We analyzed the impact of timing of thyroidectomy on overall survival (OS) in PTC.
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, accounting for 2.9% of new cancer cases. Decreased mortality and longer survival raise concern for development of SPC. Studies cite up to a 10% rate of SPC after DTC, with increased incidence of SPC among patients with PTC. Radioactive iodine therapy (RAIT) is implicated as a potential reason for SPC. We aimed to determine the incidence of SPC, associated mortality, and relationship with RAIT.
To investigate the molecular mechanism of lncRNA AP000472.2 promoting proliferation, invasion and metastasis of papillary thyroid carcinoma(PTC).
Claudia E. Rübe Carl Mann H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ ...
Conclusion: The response to initial surgery and radioiodine therapy in PDTC patients can achieve an excellent outcome and a further follow-up should be refined based on findings at the first diagnostic control. However, patients with an incomplete response and metastatic patients who become mostly radioiodine refractory show a significantly shorter survival, which makes accurate staging by 18F-FDG-PET/CT imaging crucial.
ConclusionThe combined radiomics model is a non-invasive preoperative tool that incorporates radiomic features and clinical risk factors to predict CLNM in patients with PTC.
CONCLUSIONS.—: A significant proportion of TOETVA specimens are disrupted/fragmented, which can compromise information about tumors, including size, number, margin status, and microscopic extrathyroidal extension. Given that these parameters inform treatment and follow-up, this should be considered when selecting patients for TOETVA.PMID:34669921 | DOI:10.5858/arpa.2021-0082-OA
Over the past several years, the standards of endocrine surgical care have trended towards the minimum necessary surgery for patients with differentiated thyroid cancer (DTC) with the goal of balancing appropriate cancer treatment with minimizing treatment-related morbidity. Recent literature has suggested that active surveillance is sufficient for select patients with papillary thyroid microcarcinoma (PTMC) limited to the thyroid. Similarly, The American Thyroid Association 2015 guidelines for the management of DTC suggest thyroid lobectomy as an alternative to total thyroidectomy for papillary thyroid cancers
ConclusionFTI are a common finding on 18F-FDG PET/CTs. Nodules are malignant in approximately one third of the cases, with the majority being PTC. Cytology results are non-diagnostic or indeterminate in one fifth of FNACs. These findings reveal the potential risk of overdiagnostics of FTI and emphasize that the workup of FTI should be performed within the context of the patient’s disease and that guidelines should adopt this patient tailored approach.