GSE184362 Single-cell sequencing of tumor ecosystems in papillary thyroid carcinoma

Contributors : Weilin Pu ; Xiao Shi ; Pengcheng Yu ; Meiying Zhang ; Xiaoming Zhang ; Yulong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profiled transcriptomes of 158,577 cells from 11 patients ’ paratumors, localized/advanced tumors, initially-treated/recurrent lymph nodes and radioactive iodine (RAI)-refractory distant metastases, covering comprehensive clinical courses of PTC.Our study illuminates a comprehensive landscape of PTC ecosystem that suggests potential prognostic and therap eutic implications. Our work not only adds dimensions to the biological underpinnings of PTC heterogeneity, but also provides a benchmark dataset for this malignancy.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research