B's in prereqs in the context of transcript repair?
I am working on transcript repair because of too many withdrawals from now-resolved health issues. I had an off-start to the semester but am doing better. That said, I think there's a good chance I am going to get B's in two of my classes. Both of them science. :/ One of them Organic Chemistry. I've gotten all A's until now in my transcript repair. I was under the impression that I had to and a B would detract from the transcript repair. Is just a couple of B's okay even in the context of... Read more
DNA Repair Interest Group videoconferenceAir date: 11/16/2021 12:30:00 PM
Conditions: Inguinal Hernia; Surgery Intervention: Device: Adhesix mesh Sponsor: Helsinki University Central Hospital Recruiting
The Food and Drug Administration (FDA) has granted accelerated approval to dostarlimab-gxly (Jemperli) for the treatment of adults with mismatch repair deficient recurrent or advanced endometrial cancer and solid tumors.
Very old flies cease to age, at least under the definition of aging as the rise of mortality rate with age. Very old flies have a high mortality rate, but that rate plateaus. There has been some back and forth over the years as to whether such a late life plateau in mortality rates can be observed in humans. Presently the consensus is that it is not apparent. It is, however, challenging to draw any robust conclusions on human mortality past the age of 110, as there are so very few survivors to that late stage of life. All of this is fascinating from a scientific point of view, but something of a sideshow when it comes to t...
Biomed Res Int. 2021 Oct 13;2021:8972074. doi: 10.1155/2021/8972074. eCollection 2021.ABSTRACTAging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, sen...
CONCLUSIONS: TEP-IHR in hemophiliacs with RT is feasible and as effective for preventing hernia recurrence as in NH-patients. In hemophiliacs risk of bleeding complications and demand for painkillers are comparable to non-hemophiliacs although pain is more intense.PMID:34691305 | PMC:PMC8512501 | DOI:10.5114/wiitm.2021.103953
Ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are both associated with endometriosis but differ in histologic phenotype, biomarker profile, and survival. Our objectives were to refine immunohistochemical (IHC) panels that help distinguish the histotypes and reassess the prevalence of mismatch repair deficiency (MMRd) in immunohistochemically confirmed OCCC. We selected 8 candidate IHC markers to develop first-line and second-line panels in a training set of 344 OCCC/OEC cases. Interobserver reproducibility of histotype diagnosis was assessed in an independent testing cohort of 100 OCC/OEC ini...
To develop a mechanistic model which describes and predicts radiation response after combined DNA damage repair (DDR) interference and particle radiotherapy.
ConclusionHigh-risk features are prognostic in the setting of dMMR/MSI-H stage II CC. Adjuvant chemotherapy may improve survival specifically in patients ≥65 years and with high-risk features.
This article will summarize the role of both endogenous and exogenous VEGF in tendon healing and discuss possible reasons for the controversy. The present review shows that tendon repair is facilitated only by proper angiogenesis and VEGF at the early stage, whereas the persistent high VEGF expression and prolonged presence of blood vessels may impair tendon repair at a later stage.