Autoimmune & inflammatory nmd

Systemic sclerosis (SSc) is a multisystemic fibrotic autoimmune disease that involves the muscles. Two muscular forms were described: the SSc myositis and myopathy. The SSc myopathy is characterized by three main histopathological findings: fibrosis, microangiopathy and type-II fiber atrophy. Quantifying these features is important to enable staging the disease, establishing a prognostic tool and linking it with systematic involvement. Muscle biopsies from 22 SSc patients and seven controls (patients with histologically normal muscle) were sectioned and stained for the pathological features of SSc myopathy.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research