Autoimmune & inflammatory nmd

Dermatomyositis is a systemic idiopathic inflammatory disease affecting skeletal muscle and skin, clinically characterized by symmetrical proximal muscle weakness and typical skin lesions. Recently, myositis-specific autoantibodies (MSA) became of utmost importance because they strongly correlate with distinct clinical manifestations and prognosis. Antibodies against transcription intermediary factor 1 γ (TIF-1γ) are frequently associated with increased risk of malignancy, a specific cutaneous phenotype and limited response to therapy in adult DM patients.

Source: Neuromuscular Disorders - September 19, 2021 Category: Neurology Authors: C. Preusse, P. Eede, L. Heinzerling, K. Freitag, R. Koll, W. Froehlich, U. Schneider, Y. Allenbach, O. Benveniste, A. Sch änzer, H. Goebel, W. Stenzel, J. Radke Source Type: research