Cancers, Vol. 13, Pages 4689: CYP3A Activity in End-of-Life Cancer Patients Measured by 4 β-Hydroxycholesterol/cholesterol Ratio, in Men and Women

Cancers, Vol. 13, Pages 4689: CYP3A Activity in End-of-Life Cancer Patients Measured by 4β-Hydroxycholesterol/cholesterol Ratio, in Men and Women Cancers doi: 10.3390/cancers13184689 Authors: Helena Bergström Maria Helde Frankling Caritha Klasson Anita Lövgren Sandblom Ulf Diczfalusy Linda Björkhem-Bergman More than 50% of all drugs are metabolized by the cytochrome P450 3A enzyme (CYP3A). The aim of this study was to investigate if the CYP3A activity, measured by the endogenous marker 4β-hydroxycholesterol/cholesterol ratio (4β-OHC/C), is changed during the last weeks and days of life in men and women. To this end, serum samples from 137 deceased patients (median age 70 years) collected at a single time point 1–60 days before death, were analyzed and compared to 280 young (median 27 years), and 30 elderly (median age 70 years) non-cancer controls. There were no significant differences in the 4β-OHC/C ratio between men and women in end-of-life patients (p < 0.25). The median 4β-OHC/C was significantly higher in end-of-life male patients compared to both young (p < 0.0001) and elderly (p < 0.05) male controls. In a similar manner, 4β-OHC/C in end-of-life female patients was significantly higher compared to young and elderly female controls, p < 0.0001 and p < 0.001, respectively. There was no significant correlation between 4β-OHC/C and survival time. The results from this study suggest mainta...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research