Correction to: Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B –5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark

Source: Archives of Osteoporosis - Category: Orthopaedics Source Type: research

Related Links:

AbstractBone turnover markers (BTMs) are released during the bone remodelling cycle and are measurable in blood or urine, reflecting bone remodelling rate. They have been useful in elucidating the pharmacodynamics and effectiveness of osteoporosis medication in clinical trials and are increasingly used in routine clinical management of osteoporosis, especially for monitoring therapy, in addition to their use in other metabolic bone disease such as Paget ’s disease of bone and osteomalacia. Serum β isomerised C-terminal telopeptide of type I collagen and pro-collagen I N-terminal propeptide have been designated a...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Abstract The European Renal Association –European Dialysis and Transplant Association (ERA-EDTA) CKD-MBD working group, in collaboration with the Committee of Scientific Advisors of the International Osteoporosis Foundation, published a position paper for the diagnosis and management of osteoporosis in patients with CKD stages 4–5D (e GFR
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewTo describe the methods that can be used to obtain functional and mature osteoclasts from peripheral blood mononuclear cells (PBMCs) and report the data obtained with this model in two peculiar diseases, namely pediatric chronic kidney disease-associated mineral and bone disorders (CKD-MBD) and nephropathic cystinosis. To discuss future research possibilities in the field.Recent FindingsBone tissue undergoes continuous remodeling throughout life to maintain bone architecture; it involves two processes: bone formation and bone resorption with the coordinated activity of osteoblasts, osteoclasts, and...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Am J Nephrol. 2021 Nov 9:1-17. doi: 10.1159/000519811. Online ahead of print.ABSTRACTBACKGROUND: The kynurenine pathway (KP) is the major catabolic pathway for tryptophan degradation. The KP plays an important role as the sole de novo nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in normal human physiology and functions as a counter-regulatory mechanism to mitigate immune responses during inflammation. Although the KP has been implicated in a variety of disorders including Huntington's disease, seizures, cardiovascular disease, and osteoporosis, its role in renal diseases is seldom discussed.SUMMARY: This r...
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionHyperpolypharmacy is associated with an increased risk of fragility fracture regardless of CKD status, and has a strong impact on incident fragility fractures in dialysis-dependent CKD patients.
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewChronic kidney disease mineral and bone disease (CKD-MBD) is a common complication of kidney disease and is strongly influenced by diet. The purpose of this manuscript is to review recent advances in the role of diet in CKD-MBD over the last 5 years.Recent FindingsMany of the recent studies examining the role of diet in CKD-MBD have focused on the adverse effects of high phosphorus consumption on bone health and metabolism. In general, the studies have shown that high phosphorus consumption worsens markers of bone and mineral metabolism but that eating a diet with a calcium to phosphorus ratio clos...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Cardiovascular disease (CVD) and osteoporosis often occur together, suggesting an association between CVD and bone loss. Similarly, the correlation of bone loss, atherosclerosis, and aortic calcification, especially in patients with chronic kidney disease, exemplifies a bone-vessel connection. In this issue of the JCI, Santhanam et al. investigated the role of the angiogenesis factor platelet-derived growth factor–BB (PDGF-BB) in vascular stiffening. Serum levels of bone-derived PDGF-BB differed between young and aged mice, and in mice fed a high-fat diet (HFD) compared with those fed normal chow. Experiments with ge...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractPurpose of ReviewChronic hepatitis B (CHB) remains a major global contributor to liver related morbidity and mortality. Currently available first line therapies offer all oral, highly effective, and safe treatment options for suppression of hepatitis B virus (HBV) and reduce long-term CHB-related complications. This review summarizes some of the more recent real-world data on the safety and effectiveness of oral nucleos(t)ide analogs in the treatment of CHB.Recent FindingsCurrent first line CHB oral treatment options include entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF). Rece...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals https://www...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them.
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
More News: Chronic Kidney Disease | Denmark Health | Orthopaedics | Osteoporosis | Urology & Nephrology | Women