Reversal of elastase-induced abdominal aortic aneurysm following the delivery of nanoparticle-based pentagalloyl glucose (PGG) is associated with reduced inflammatory and immune markers

CONCLUSION: Nanoparticles-loaded pentagalloyl glucose therapy can be an effective treatment option against advanced stage aneurysms to reverse the disease by ameliorating inflammation and restoring arterial homeostasis.PMID:34516951 | DOI:10.1016/j.ejphar.2021.174487
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research

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The introduction of endovascular abdominal aortic aneurysm repair (EVAR) led to a reduction in open repair (OAR) cases, raising concerns regarding patient safety and future training of vascular surgeons. Our objective is to analyze trends in OAR and EVAR cases and their implications on vascular surgery training.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Surgical Education Source Type: research
Surveillance imaging receipt post-abdominal aortic aneurysm (AAA) repair is generally poor and declines over time. Here we evaluate rates of guideline-complaint imaging following AAA repairs in the Veterans Administration (VA) system which may have fewer barriers to accessing care.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Vascular Surgery Source Type: research
There is much evidence that perivascular adipose tissue plays a role in vascular homeostasis as well as the progression of vascular disease states. Multiple studies have demonstrated differences in perivascular adipose tissue in regards to density around diseased vs healthy segments of the aorta, and differences in the transcriptome of PVAT in these two populations. Our study aimed to define the differences in protein levels between PVAT surrounding diseased and healthy aortic segments in patients with abdominal aortic aneurysms.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Vascular Surgery Source Type: research
Despite improvements in screening, diagnostics, as well as repair methods for abdominal aortic aneurysms (AAA), disparities continue to prevail in non-white vs white patients. We aim to describe differences in surgical outcomes between ethnic groups undergoing repair for non-ruptured AAA.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Vascular Surgery Source Type: research
The effect of body mass index (BMI) on vascular surgery has been studied, but relative risks in repair of abdominal aortic aneurysms (AAA) is underreported. We studied the “obesity paradox” in patients undergoing open vs. endovascular AAA repair to determine risk associated with BMI in this high-risk cohort.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Vascular Surgery Source Type: research
This study aims to assess the content and quality of current videos of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA) on YouTube.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Vascular Surgery Source Type: research
Abdominal Aortic Aneurysm (AAA) is a common progressive disease and a significant cause of morbidity and mortality. Prior investigations have shown that diabetes mellitus (DM) may be relatively protective of AAA incidence and growth. The Non-invasive Treatment of Aortic Aneurysm Clinical Trial (N-TA3CT) is a contemporary study of small AAA growth which provides a unique opportunity to validate and explore the effect of DM on AAA. Confirming the effect of DM on AAA growth in this study may present opportunities to explore for clues to potential biologic mechanisms as well as inform current patient management.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
While efforts such as the Screening Abdominal Aortic Aneurysms Very Efficiently (SAAAVE) Act have improved access to abdominal aortic aneurysm (AAA) screening, certain high-risk populations are currently excluded from the guidelines yet may benefit from screening. We therefore examined all patients who underwent repair of ruptured AAA (rAAA) to characterize those who are ineligible for screening under current guidelines and evaluate the potential impact of these restrictions on their disease.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Previous studies on the relationship between positron emission tomography (PET) images and abdominal aortic aneurysm (AAA) progression have shown contradictory results, and the objective of this study was to systematically review the role of PET in predicting AAA prognosis.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Tags: Systematic Review Source Type: research
CONCLUSIONS: This study suggests that EVAR cannot improve survival outcomes compared with OSR if applied solely because a patient is aged ≥80 years. Not only age but also other risk factors and quality of life after surgery need to be further studied.PMID:34670876 | DOI:10.1253/circj.CJ-21-0574
Source: Circulation Journal - Category: Cardiology Authors: Source Type: research
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